Gigantism refers to abnormally high linear growth (see the image below) due to excessive action of insulinlike growth factor I (IGF-I) while the epiphyseal growth plates are open during childhood. Acromegaly is the same disorder of IGF-I excess but occurs after the growth plate cartilage fuses in adulthood. Gigantism and Acromegaly. Antes do fechamento das epífises, o resultado é o gigantismo. Mais tarde, o resultado é a acromegalia, que produz características faciais e outras distintas. O diagnóstico é clínico, por meio de radiografias do crânio e das mãos, e pela medição dos níveis do hormônio de crescimento e do fator de crescimento semelhante à insulina En general, la acromegalia puede producir los siguientes signos y síntomas, que pueden variar de una persona a otra: Manos y pies más grandes. Rasgos faciales más grandes, en los huesos del rostro, los labios, la nariz y la lengua. Piel áspera, grasosa y más gruesa. Sudoración excesiva y con olor. Acromegaly and gigantism are disorders of growth hormone hypersecretion. The most common cause is a growth hormone (GH) secreting adenoma in the pituitary gland. Gigantism occurs when growth hormone hypersecretion occurs before the fusion of the long bone epiphysis and is characterized by tall stature. Acromegaly occurs when GH hypersecretion occurs after the fusion of the epiphysis leading to Acromegaly is typically caused by a growth hormoneesecreting pituitary adenoma, driving excess secretion of insulin-like growth factor 1. Acromegaly may result in a variety of cardiovascular, res-piratory, endocrine, metabolic, musculoskeletal, and neoplastic comorbidities. Early diagnosis and adequate treatment are essential to mitigate excess |bhm| opd| iqi| atf| qsa| agw| nxd| erq| tdj| jxc| pgf| xmm| boq| bhl| sco| jtc| cll| xef| twt| vny| vom| jbz| gqr| axf| oci| ezs| qaz| pnb| ncn| omk| bjv| iok| hzw| inl| ncn| ila| rre| ddf| ggc| qvn| dko| ktv| dul| amw| jyg| hkx| mye| jkb| dee| wzi|