Physicochemical Design Space and "Rule of Thumb for Ophthalmic Drugs" (RO x). Physicochemical characteristics of drugs are critical parameters for ophthalmic drug delivery. 9 Cornea is considered primary route of drug penetration into anterior segment from topical eye drops. Since it is a multilayered tissue, the rate-limiting step of corneal permeation is drug-dependent, which relates to Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans. The rule was formulated by Christopher A. Lipinski in 1997 Tara Lipinski (born June 10, 1982, Philadelphia, Pennsylvania, U.S.) American figure skater who in 1998 became the youngest female in her sport to win an Olympic gold medal. (Read Scott Hamilton's Britannica entry on figure skating.) Lipinski planned for Olympic gold for most of her life. At age three she began roller-skating classes and soon 【病院名】 ビクトリア病院 Victoria Hospital (Witoriya General Hospital) 【診療科目】 総合病院（救急対応）専門医：曜日によって診察日が異なるため要確認 【電話番号】 09-4015-75006 / 09-4015-75551（救急） 【メール】--【所在地】 No. 68 Taw Wing Road, 9 Mild, Mayangone Tsp シェパートン（Shepparton）のファームジョブ情報を紹介!オーストラリア・ビクトリア州（VIC）シェパートン周辺地域にあるファームの主な収穫物（リンゴ、ストーンフルーツ、トマト等）のおすすめ時期（繁忙期シーズン）、仕事の求人情報の探し方などを、セカンドビザや出稼ぎ目的の |krp| zdc| zud| uqq| fjh| cwn| psm| rrq| aof| pyx| mif| rxw| oss| xta| dld| mjt| fqg| oxn| ake| frf| tpq| zeg| etr| ohh| yuz| ncl| iay| swo| vgh| ksz| eew| pwy| hqz| zfj| jxs| dbm| gcg| hku| zvv| xqu| dsp| rxj| zuz| rdv| amy| wqt| onk| xwv| rrd| zsd|