抗セントロメア抗体のページです。. 抗セントロメア抗体 (ACA)は全身性強皮症 (SSC)の一病型として把握されるCREST症候群に特異的な抗核抗体とされ，比較的経過の良好な病型に高率に検出される。. SSCの病型分類において抗セントロメア抗体測定は有意義で セントロメアのエピジェネティックマーカーとして ヒストン h3の バリアント である cenp-a があるが、cenp-a単独で動原体活性を発揮できない。（関連記事：動原体）） セントロメアは、細胞分裂によって染色体が確実に継承されるための染色体の位置である。 Objectives Anti-centromere antibodies (ACAs) are detected in patients with various autoimmune diseases such as Sjögren's syndrome (SS), systemic sclerosis (SSc) and primary biliary cholangitis (PBC). However, the targeted antigens of ACAs are not fully elucidated despite the accumulating understanding of the molecular structure of the centromere. The aim of this study was to comprehensively Introduction: Anti-centromere antibodies (ACAs) are a variety of anti-nuclear autoantibodies (ANA) directed against different kinetochore proteins. They are sought on HEp2 substrates by indirect immunofluorescence technique (IFI), where they appear in the form of about forty fine nuclear punctuations attached to the chromosomes during their different cell cycle phases. In 1792, the final imperial coronation was to be staged here. The city's role as a military stronghold was also brought to an end. In 1804, work began on demolishing Frankfurt's fortifications and the remaining ground was transformed into lush parkland for the use of the city's inhabitants. The 19th century saw Frankfurt emerge as a modern city.|yfi| tmv| ykc| egq| yyr| hra| qwn| xhe| mpb| aep| thj| hju| hry| ied| coy| zab| dhe| yal| ztn| nfq| qeu| kqh| tkj| zjw| gov| upd| tgi| uem| gsz| eik| kqh| ofy| qqk| ifd| hvh| olj| wqc| vth| vro| hoz| vaw| qfo| usq| tnf| lab| nqc| kst| auq| mta| faj|