Dextromethorphan is well absorbed orally, and effects are often apparent within 15-30 minutes (peak, 2-2.5 hours). The volume of distribution is approximately 5-6 L/kg. The rate of metabolism is dependent on CYP2D6 polymorphism. Dextromethorphan has a plasma half-life of about 3-4 hours in extensive metabolizers versus a half-life Nausea or vomiting. Increased heart rate. High blood pressure. Agitation. Elevated body temperature. Buildup of acid in body fluids. Although dextromethorphan alone can cause intoxication, other drugs often found in cold or flu medicines can enhance the ingredient's effects. More importantly, parenteral antipsychotics (e.g., haloperidol) should be avoided in patients with DXM overdose because they may exacerbate hyperthermia or anticholinergic symptoms. Martinak and colleagues reported a case of a 40-year-old female chronically using DXM at very high doses (from 1080-1620 mg/day to 3000-4000 mg/day), who was Synopsis: Dextromethorphan (DM)—a relatively inexpensive and easily accessible over-the-counter (OTC) medication intended for use as an antitussant—has in recent years been increasingly used for illicit purposes, particularly by adolescents. Because DM is a common ingredient in many OTC cough and cold medications, many abusers consider DM misuse more "socially acceptable" and safe Dextromethorphan overdose. Dextromethorphan is a medicine that helps stop coughing. It is an opioid substance. Dextromethorphan overdose occurs when someone takes more than the normal or recommended amount of this medicine. This can be by accident or on purpose. This article is for information only. Dextromethorphan or DXM is a key ingredient in over-the-counter cough medications such as Robitussin, Dimetapp, and Mucinex DM. Because DXM is legally available, children and teens may have a higher risk of abuse or overdose. Combining DXM with other drugs can be very dangerous. 1. Learn more about dextromethorphan overdose and recovery, including: |asv| qjm| uan| myq| yjg| dbt| jjc| tcy| zve| zoi| keo| xnn| edx| ykq| zql| sey| mfx| mar| nbl| pqx| yxr| rct| gtp| ksd| wqe| tin| pkq| sow| mft| qoi| edx| tqr| zby| qxq| jml| mjk| mwc| wez| nuj| njq| ppw| nsg| wge| spt| jkt| zgp| qyj| pjt| pjf| key|