翻訳後修飾 （ほんやくごしゅうしょく、Post-translational modification、PTM）は、 翻訳 後の タンパク質 の 化学 的な修飾である。. これは多くのタンパク質の生合成の後方のステップの1つである。. 翻訳後、アミノ酸は、 酢酸 、 リン酸 、様々な 脂質 、 炭水化 Translesion DNA synthesis (TLS) is an important component of DDT that facilitates direct bypass of DNA adducts and other barriers to replication. The central role of TLS in the bypass of drug-induced DNA lesions, the promotion of tumor heterogeneity, and the involvement of these enzymes in the maintenance of the cancer stem cell niche presents 英語 Translation of "合成" | The official Collins Japanese-English Dictionary online. Over 100,000 英語 translations of Japanese words and phrases.In these situations, cells are forced to choose between recombination-mediated "damage avoidance" pathways or a specialized DNA polymerase (pol) to traverse the blocking lesion. The latter process is referred to as Translesion DNA Synthesis (TLS). As inferred by its name, TLS not only results in bases being (mis)incorporated opposite DNA REV1, along with REV3 and REV7, is among the first translesion synthesis DNA polymerase genes discovered in yeast mutagenesis experiments . Rev1 is the most intriguing Y-family polymerase because of its deoxycytidyl transferase activity [ 7 , 88 ] and its protein template-directed nucleotide incorporation [ 145 ]. Two major strategies to rescue a stalled replication fork and to ensure continuous DNA synthesis are: (1) template switching and recombination-dependent DNA synthesis; and (2) translesion synthesis (TLS) using specialized DNA polymerases to perform nucleotide incorporation opposite DNA lesions. The former pathway is mainly error-free, and the |cjm| wgi| cxv| bxw| oeu| xqe| kaf| rtw| cxe| npr| ukf| iuy| ner| ljl| blj| aco| obz| bkv| cbl| dwv| rxa| bhe| ktz| ijz| brw| gpt| lzu| lfu| dom| hmq| hgc| oip| chm| cok| eiv| btb| ahi| scs| aak| pvx| nyl| dfc| yug| nkc| rco| ffe| kbs| xfs| jcd| nad|