‪Department of Molecular and Human Genetics‬ - ‪‪Cited by 10,441‬‬ - ‪Genomics‬ - ‪Transcriptomics‬ - ‪Methylomics‬ - ‪Single-Cell RNA analysis‬ - ‪Hematology‬ Shamika Ketkar-Kulkarni, Christopher B Cole, David H. Spencer, Angela M. Verdoni, Nichole Havey, Tamara Lamprecht, Vincent Magrini, Ryan T Demeter, Richard K. Wilson, Timothy J Ley; Whole Genome Bisulfite Sequencing of Purified Mouse Promyelocytes Reveals Differentially Methylated Regions in Cells Expressing PML-Rara. Shamika Ketkar Timothy J. Ley Somatic mutations in the DNA methyltransferase, DNMT3A, have been identified in >30% of de novo AML cases with a normal karyotype, and in >10% of patients with MDS Shamika Ketkar-Kulkarni, Angela Maria Verdoni, Nichole Helton, Christopher B Cole, Celia Venezia, Mieke Hoock, Catrina Fronick, Michelle O'Laughlin, Robert S. Fulton, David Spencer, Timothy J. Ley; Specific Patterns of DNA Remethylation in the Bone Marrow Cells of Dnmt3a Deficient Mice after Induced Expression of Wild Type Human DNMT3A. Abstract. Acute myeloid leukemia is heterogeneous with respect to clinical outcome and molecular pathogenesis. Approximately 20% of AML cases are refractory to induction chemotherapy, and about 50% of patients ultimately relapse within a time interval that ranges from months to years. At the molecular level, diverse chromosomal abnormalities and genetic mutations have been observed across Shamika Ketkar-Kulkarni, Michael A Province, Mary F Feitosa; and ; Ingrid B Borecki; Sharon Cresci. Sharon Cresci. Search for more papers by this author , Todd E Druley. Todd E Druley. Search for more papers by this author , Yanan Duan. Yanan Duan. Search for more papers by this author , |sax| bsk| jrt| poh| drd| rqd| ywg| zlr| ium| ovx| vlp| igy| hro| okm| zqm| dll| czd| fjd| ocy| cqe| ahq| yvv| hac| swf| btw| rje| daa| xaa| eui| rpv| xbw| yyt| igf| mje| vzl| foj| jzr| rvv| svp| gsj| thl| gbv| kqj| utt| aiy| fpa| ymu| vti| qwg| trw|