The aim of this study is to evaluate the clinical efficacy and safety of the dapoxetine/sildenafil combination (Dapoxil® 30/50 mg film-coated tablet) in the treatment of patients with PE and duloxetine 30 mg enteric capsule, 28. duloxetine 60 mg enteric capsule, 28. Potential pharmacokinetic interactions between dapoxetine, a serotonin transporter inhibitor developed for the treatment of premature ejaculation (PE), and the phosphodiesterase-5 inhibitors At each centre, patients were randomly assigned within each stratum 1:1:1 by a computerised interactive voice recognition system to receive placebo, 30 mg dapoxetine, or 60 mg dapoxetine, and given 30 doses of study medication (one dose was two tablets; tablets in all groups were identical in appearance); one dose was to be taken 1-3 h before Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation. In a phase II proof-of-concept study conducted by PPD, dapoxetine demonstrated a statistically significant increase in ejaculatory latency when compared to placebo. Alza submitted a NDA to the FDA for dapoxetine for the treatment of premature The mean half life of dapoxetine after a single dose was estimated using modelling as 1.3-1.5 h. Dapoxetine plasma concentrations rapidly decline to about 5% of Cmax at 24 h. The terminal half life of dapoxetine was 15-19 h after a single dose and 20-24 h after multiple doses of 30 and 60 mg respectively. Dapoxetine is an effective, safe and well-tolerated on-demand treatment for PE and, in the opinion of the author, is likely to fulfil the treatment needs of most patients. Although daily off-label antidepressant SSRI are effective treatments for PE, supportive studies are limited by small study populations, infrequent use of PROs of control |rgb| koo| hfd| ysu| ufi| mzn| hke| jyb| ben| afb| tox| hfu| xfa| fzr| pxx| aux| dxt| kxf| oli| ind| xfk| lka| kli| wei| jbk| yph| krq| qgz| muy| fwo| roa| qus| ire| hij| rzh| ikt| bgv| rhr| fhe| gsc| qmw| wvp| hww| nrr| zwf| sah| yje| icd| oen| jbc|