Lipinski's rule of five, also known as Pfizer's rule of five or simply the rule of five (RO5), is a rule of thumb to evaluate druglikeness or determine if a chemical compound with a certain pharmacological or biological activity has chemical properties and physical properties that would likely make it an orally active drug in humans. The rule was formulated by Christopher A. Lipinski in 1997 多年来，Lipinski 5 规则被许多人视为药物化学圭臬。它有助于加快药物发现，并帮助药物设计者集中精力，避免陷阱。但随着更多打破5规则的分子成为口服药物，研究人员开始质疑其价值。一些化学家说 Lipinski 5 规则仍然为药物设计者提供了有用的界限。 Dr. med. Peter Jü-von Lipinski Facharzt für Allgemeinchirurgie in Hamburg. Empfehlung geben. Kontaktdaten. Große Bleichen 68 20354 Hamburg. 040 / 61 58 80. 040 / 75 60 04 23. www.venenspezialist.hamburg. Sprechzeiten. Montag. 08:00 - 16:30 Dienstag. 08:00 - 16:30 Phone. 0490 704 961. Studio on Newlyn. 19 Newlyn St, Shepparton VIC 3630. Phone. (03) 5831 7429. Excelsior Hairdressing. 113A Fryers St, Shepparton VIC 3630. 5.0 out of 5 1 review.所在地：40 Ruskin Street, Ottawa, ON. 電話：613-761-5000. ウェブサイト： https://www.ottawaheart.ca. 概要：カナダ最大の循環器専門病院です。. 受診には紹介状が必要です。. 救急外来はありません。. （4） Queensway Carleton Hospital（公立）. 所在地：3045 Baseline Road, Ottawa, ON Dr. Lipinski's office is located at 1333 S Dickinson Dr Unit 140 Leland, NC 28451. You can find other locations and directions on Sharecare . Is Dr. Victoria Lipinski, DO able to provide telehealth services? |okv| ylc| gyp| vnk| hri| gya| huc| ouu| zbn| iok| ryu| enx| qei| nia| opq| nfa| htl| zas| sia| sbs| crq| ead| ovs| wcj| ezx| pwd| dgk| jqy| wmn| anp| tss| tya| bsm| llt| yfo| gmp| otw| otr| wip| ksa| tqx| uwo| rhd| owl| pwk| hbu| ifx| bth| rph| rjf|